BDB559027
MCL-1 Mouse anti-Human, Unlabeled, Clone: 22, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB559027-Each-of-1 | In Stock | ₹ 32,040.00 |
BDB559027 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 32,040.00
GST (18%): ₹ 5,767.20
Total Price: ₹ 37,807.20
Antigen
MCL-1
Classification
Monoclonal
Concentration
0.5mg/mL
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
Purified recombinant human Mcl-1 lacking the C-terminal hydrophobic domain
Quantity
0.1 mg
Research Discipline
Cell Biology
Target Species
Human
Isotype
IgG1 κ
Applications
Western Blot
Clone
22
Conjugate
Unconjugated
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C
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Description
- The Bcl-2 family of proteins plays a pivotal role in determining the life and death of a cell
- Members of the Bcl-2 family all possess at least one of four conserved Bcl-2 homology domains (BH1-BH4) which mediate protein-protein interactions
- They can be divided into molecules that have either an anti-apoptotic or pro-apoptotic function
- The ratio between these two groups of molecules can help determine whether a cell lives or dies
- The majority of anti-apoptotic family members contain common BH1-BH4 domains and are most similar to Bcl-2
- Mcl-1 is a member of the anti-apoptotic Bcl-2 group of proteins, including Bcl-x, Bcl-w, A1/Bfl-1, Boo/Diva, and Nr-13
- Mcl-1 was cloned from the ML-1 human myeoblastic leukemia cell line
- Mcl-1 localizes to the mitochrondria, like Bcl-2, but also associates with membranes via its C-terminal hydrophobic domain
- Further studies have shown that Mcl-1 is upregulated in response to the GM-CSF and IL-3 cytokine signaling pathways and that this regulation of Mcl-1 is controlled at the level of transcription
- Mcl-1 is detected at approximately 40kDa in SDS/PAGE
- Immunoprecipitation, Western Blotting