CD227 Mouse anti-Human, FITC, Clone: HMPV, BD

Description

• The HMPV monoclonal antibody specifically binds to CD227 which is also known as Mucin-1 (MUC1)
• A major form of CD227 is expressed as a type I transmembrane glycoprotein
• CD227 belongs to the epithelial mucin family whose members are heavily O-glycosylated and characterized by high molecular weight, and an amino acid composition rich in serine, threonine, proline, and glycine
• CD227 is variably expressed on the surfaces of normal and malignant glandular and ductal epithelial cells, and some hematopoietic cell lineages including subsets of T cells, B cells, monocytes and dendritic cells
• Soluble forms of CD227 may arise by shedding from the cell surface or by secretion of forms derived from alternative RNA splicing
• The HMPV antibody binds to the core peptide of the MUC1 protein
• The core protein contains a domain of 20 amino-acid tandem repeats which function as multiple epitopes for this monoclonal antibody
• Incomplete glycosylation of some tumor-associated mucins may lead to variable unmasking of the multiple peptide epitopes leading to the observed differences in immunostaining intensities between cells from normal and malignant tissues
• CD227 plays roles in the provision of protective barrier function, the regulation of cellular adhesion, and the transduction of multiple signal pathways.