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BDB559788

CD226 Mouse anti-Human, FITC, Clone: DX11, BD

Manufacturer: BD Biosciences

Select a Size

Pack Size SKU Availability Price
Each of 1 BDB559788-Each-of-1 In Stock ₹ 27,901.50

BDB559788 - Each of 1

₹ 27,901.50

In Stock

Quantity

1

Base Price: ₹ 27,901.50

GST (18%): ₹ 5,022.27

Total Price: ₹ 32,923.77

Antigen

CD226

Classification

Monoclonal

Conjugate

FITC

Formulation

Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

Immunogen

Human CTL Clone

Quantity

100 Tests

Research Discipline

Immunology

Target Species

Human

Isotype

IgG1 κ

Applications

Flow Cytometry

Clone

DX11

Description

DNAM-1; DNAM1; PTA1; PTA-1; TLiSA1

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Description

  • The DX11 monoclonal antibody specifically binds to CD226 which is also known as DNAX accessory molecule-1 (DNAM-1), Platelet and T cell activation antigen 1 (PTA1), or T lineage-specific activation antigen 1 antigen (TLiSA1)
  • CD226 is a 65 kDa type 1 transmembrane glycoprotein consisting of 318 amino acid residues including two Ig-like domains
  • CD226 is expressed on the majority of T cells, NK cells, monocytes, platelets, and a subset of B cells, but not on granulocytes or erythrocytes
  • It is also present on a subset of thymocytes coexpressing high density surface CD3
  • CD226 is not present on normal fibroblast cell lines or tumor cell lines of epithelial or neuronal origins
  • CD226 is a tyrosine phosphorylated, signal-transducing molecule which participates in primary adhesion during cytotoxic T lymphocyte (CTL)- or NK cell-mediated cytotoxicity
  • The DX11 antibody inhibits T- and NK cell-mediated cytotoxicity against a variety of tumor cell targets, and blocks cytokine production by alloantigen-specific T cells.