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BDB560318

FR4 (Folate receptor 4) Rat anti-Mouse, APC, Clone: 12A5, BD

Manufacturer: BD Biosciences

Select a Size

Pack Size SKU Availability Price
Each of 1 BDB560318-Each-of-1 In Stock ₹ 32,040.00

BDB560318 - Each of 1

₹ 32,040.00

In Stock

Quantity

1

Base Price: ₹ 32,040.00

GST (18%): ₹ 5,767.20

Total Price: ₹ 37,807.20

Antigen

FR4 (Folate receptor 4)

Classification

Monoclonal

Concentration

0.2mg/mL

Description

Folate receptor 4, FBP, FBP3, FRdelta, FRd

Host Species

Rat

Purification Method

Affinity Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Applications

Flow Cytometry

Clone

12A5

Conjugate

APC

Formulation

Aqueous buffered solution containing ≤0.09% sodium azide.

Immunogen

Mouse CD4+ CD25+ T cells

Quantity

0.1 mg

Research Discipline

Immunology

Target Species

Mouse

Isotype

IgG1

Description

  • The monoclonal antibodies TH6 and 12A5 recognize Folate Receptor 4 (FR4), also known as the membrane folate-binding protein 3 (FBP3)
  • FR4 is a heavily glycosylated 35kDa receptor expressed exclusively in lymphoid tissue and an isoform of the family of receptors that recognize the essential nutrient folic acid
  • Natural T regulatory cells constitutively express high levels of FR4
  • Differential expression of FR4 in combination with CD25 can distinguish four functionally distinct CD4+ T cell subpopulations; Natural Tregs, effector T cells, memory-like T cells and Nanve T cells
  • FR4hi CD25+ expressing CD4+ T cells also express high amounts of Foxp3, GITR and CTLA-4
  • Monoclonal antibody TH6 and 12A5 stained CD25+CD4+ T cells at a higher level than other CD4+ or CD8+ T cells
  • In addition, in vivo injection of TH6 monoclonal antibody reduced the number of CD25+CD4+ T cells and CD25-CD4+ T cells in peripheral blood
  • Clone 12A5 has been demonstrated to work in western blot
  • Clones TH6 and 12A5 do not block one another in a flow cytometric assay
  • Host Species: Rat Clone: 12A5 Isotype: IgG1 κ Species Reactivity: Mouse Immunogen: Mouse CD4+ CD25+ T cells Flow Cytometry