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BDB560465

S6 (pS244) Mouse, Alexa Fluor 647, Clone: N5-676, BD

Manufacturer: BD Biosciences

Select a Size

Pack Size SKU Availability Price
Each of 1 BDB560465-Each-of-1 In Stock ₹ 28,124.00

BDB560465 - Each of 1

₹ 28,124.00

In Stock

Quantity

1

Base Price: ₹ 28,124.00

GST (18%): ₹ 5,062.32

Total Price: ₹ 33,186.32

Antigen

S6 (pS244)

Classification

Monoclonal

Conjugate

Alexa Fluor 647

Formulation

Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

Immunogen

Phosphorylated Human ribosomal protein S6 Peptide

Quantity

50 Tests

Research Discipline

Cell Biology

Target Species

Human, Mouse, Rat

Isotype

IgG1 κ

Applications

Flow Cytometry

Clone

N5-676

Description

40S ribosomal protein S6; Phosphoprotein NP33; RPS6; RS6

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Description

  • Ribosomal protein S6 (∽29kDa calculated and ∽32kDa observed molecular weights) is a component of the 40S ribosomal subunit and belongs to the S6E family of ribosomal proteins
  • The S6 ribosomal protein plays a role in regulating the translation of RNAs and thus controlling the growth and proliferation of cells
  • S6 ribosomal protein phosphorylation, especially at multiple C-terminal serine residues S235, S236, S240, and S244, activates S6
  • The activated S6 ribosomal protein in turn upregulates the ribosomal translation of RNA species coding for other ribosomal proteins, peptide elongation factors and other proteins involved in cell cycle entry and progression
  • These phosphorylations are mediated by various kinases (e.g., p70S6K and PKCD) activated through cellular responses to growth factors, cytokines, tumor promoting agents, and mitogens
  • The S6 ribosomal protein can be dephosphorylated in growth-arrested cells
  • The N5-676 monoclonal antibody specifically detects the S6 ribosomal protein phosphorylated at S244
  • Host Species: Mouse Clone: N5-676 Isotype: IgG1 κ Species Reactivity: Human Immunogen: Phosphorylated Human ribosomal protein S6 Peptide Intracellular Staining