IL-17F Mouse anti-Human, V450, Clone: O33-782, BD

Description

• The O33-782 monoclonal antibody specifically binds to Interleukin-17F (IL-17F)
• IL-17F is a member of the IL-17 family of cytokines
• IL-17F is encoded by the IL17F gene located in chromosome 6 (location: 6p12)
• IL-17F is a proinflammatory cytokine that is produced by activated T cells including differentiated CD4+ T helper 17 (Th17) cells
• Activated Th17 cells can express disulfide-linked IL-17F and IL-17A homodimers as well as IL-17A/IL-17F heterodimers
• These IL-17 dimers act by binding to and signaling through IL-17 receptor complexes (IL-17R)
• IL-17R are comprised of transmembrane IL-17RA and IL-17-RC protein subunits that are expressed by a variety of target cells including epithelial and endothelial cells, keratinocytes, fibroblasts, and granulocytes
• IL-17F can induce target cells to produce proinflammatory cytokines such as IL-1β, IL-6, G-CSF, GM-CSF, and TNF and chemokines including CXCL1/Gro-α, CXCL2/Gro-β, and CXCL8/IL-8 that attract and activate leukocytes, eg, neutrophils
• Th17 and other IL-17F-producing cells play protective roles in the clearance of extracellular pathogens, including bacteria and fungi
• IL-17F can also play adverse roles in inflammation associated with asthma and autoimmune diseases
• Host Species: Mouse Clone: SCPL1362 Isotype: IgG1 κ Species Reactivity: Human