BDB561825
CD3e, PE-Cy5 Hamster anti-Mouse, PE-Cy5, Clone: 145-2C11, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB561825-Each-of-1 | In Stock | ₹ 8,935.60 |
BDB561825 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 8,935.60
GST (18%): ₹ 1,608.408
Total Price: ₹ 10,544.008
Antigen
CD3e
Classification
Monoclonal
Concentration
0.2mg/mL
Description
CD3; CD3 epsilon; Cd3e; CD3ε; T3e
Host Species
Hamster
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Mouse
Isotype
IgG1 κ
Applications
Flow Cytometry
Clone
145-2C11
Conjugate
PE-Cyanine5
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
H-2Kb specific cytotoxic T lymphocyte clone BM10-37
Quantity
25 μg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- The 145-2C11 monoclonal antibody specifically binds to the 25-kDa ε chain of the T-cell receptor-associated CD3 complex that is expressed on thymocytes, mature T lymphocytes, and NK-T cells
- The cytoplasmic domain of CD3e participates in the signal transduction events that activate several cellular biochemical pathways as a result of antigen recognition
- Soluble 145-2C11 antibody can activate either unprimed (naive) or primed (memory/preactivated) T cells in vivo or in vitro , in the presence of Fc receptor-bearing accessory cells
- In contrast, plate-bound 145-2C11 can activate T cells in the absence of accessory cells
- Soluble 145-2C11 antibody has been reported to induce re-directed lysis of Fc receptor-bearing target cells by CTL clones and can also block lysis of specific target cells by antigen-specific CTL's
- Under some conditions, T-cell activation by 145-2C11 antibody has been reported to result in apoptotic cell death
- The 145-2C11 antibody does not cross-react with rat leukocytes
- Preincubation of thymus cell suspensions at 37°C for 2-4 hours prior to staining reportedly enhances the ability of anti-CD3ε and anti-αβ TCR mAbs to detect the T-cell receptor on immature thymocytes.