BDB561874
CD45.2 Mouse anti-Mouse, FITC, Clone: 104, BD
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB561874-Each-of-1 | In Stock | ₹ 16,198.00 |
BDB561874 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,198.00
GST (18%): ₹ 2,915.64
Total Price: ₹ 19,113.64
Antigen
CD45.2
Classification
Monoclonal
Concentration
0.5mg/mL
Description
Ly-5.2; T200; LCA; Leukocyte common antigen; Ptprc
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Mouse
Isotype
IgG2a κ
Applications
Flow Cytometry
Clone
104
Conjugate
FITC
Formulation
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Immunogen
B10.S mouse thymocytes and splenocytes
Quantity
0.1 mg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Related Products
Description
- The 104 clone has been reported to react with CD45 (Leukocyte Common Antigen) on all leukocytes of most mouse strains (eg, A, AKR, BALB/c, CBA/Ca, CBA/J, C3H/He, C57BL, C57BR, C57L, C58, DBA/1, DBA/2, NZB, SWR, 129)
- This alloantigen was originally named Ly-5.1, and this was the designation at the time that the antibody was characterized
- The designation was later changed from Ly-5.1 to Ly-5.2 to conform with the convention that the .2 alloantigen designations be assigned to the C57BL/6 strain
- mAb 104 has been reported not to react with leukocytes of the mouse strains expressing the CD45.1 alloantigen (eg, RIII, SJL/J, STS/A, and DA)
- CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: its intracellular (COOH-terminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated A, B, and C, respectively), plus differing levels of glycosylation
- The CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific
- The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction
- The 104 antibody has been reported to inhibit some responses of B cells, from mice expressing the CD45.2 alloantigen, to certain antigens and LPS
- In addition, reduction of serum IgG levels and amelioration of autoimmune renal pathology were reported in mAb 104-treated systemic lupus erythematosus-prone mice.