BDB561911
CD61 Hamster anti-Mouse, FITC, Clone: 2C9.G2 (also known as HMβ3-1), BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB561911-Each-of-1 | In Stock | ₹ 14,658.30 |
BDB561911 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 14,658.30
GST (18%): ₹ 2,638.494
Total Price: ₹ 17,296.794
Antigen
CD61
Classification
Monoclonal
Concentration
0.5mg/mL
Description
Integrin β3 chain
Host Species
Hamster
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Mouse
Isotype
IgG1 κ
Applications
Flow Cytometry
Clone
2C9.G2 (also known as HMβ3-1)
Conjugate
FITC
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
Mouse T-cell Hybridoma 2B4 Vitronectin Receptor
Quantity
0.1 mg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Related Products
Description
- The 2C9.G2 antibody reacts with the integrin β3 chain (CD61), which associates with the integrin αv chain (CD51) to form the vitronectin receptor and with the αIIb chain (CD41) to form the gpIIb/IIIa complex
- Both receptors mediate adhesion to fibronectin, fibrinogen, vitronectin, thrombospondin, and von Willebrand factor
- Leukocyte-endothelial adhesion is also mediated by the binding of αvβ3 integrin or vitronectin receptor to CD31 (PECAM-1)
- In addition, interaction of the αvβ3 integrin with its ligands regulates the L-type Ca2+ channel in vascular smooth muscle cells, possibly mediating vasodilatory responses to injury
- Soluble and insoluble 2C9.G2 mAb mimics the effect of the natural ligands in smooth muscle cells from rat cremaster arterioles
- Furthermore, osteopontin, also named Eta-1, is a cytokine that binds to αvβ3
- CD61 is expressed on platelets, activated T lymphocytes, polymorphonuclear granulocytes, and blastocysts
- Cross-reactivity of mAb 2C9.G2 to rat mast cells and platelets has been observed by flow cytometric analysis
- mAb 2C9.G2 has been demonstrated to block binding of rat and mouse cells to fibronectin.