BDB562064
NKG2D Mouse anti-Human, APC, Clone: 1D11, BD
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB562064-Each-of-1 | In Stock | ₹ 14,596.00 |
BDB562064 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 14,596.00
GST (18%): ₹ 2,627.28
Total Price: ₹ 17,223.28
Antigen
NKG2D
Classification
Monoclonal
Conjugate
APC
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG1 κ
Applications
Flow Cytometry
Clone
1D11
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
NKL cells
Quantity
25 Tests
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- The 1D11 monoclonal antibody specifically binds to NKG2D, a 42 kDa type II transmembrane glycoprotein that is also known as CD314 and KLRK1
- NKG2D is a member of the C-type lectin family and is expressed on human NK cells
- This activating receptor binds strongly to several ligands including MICA and MICB and ULBP-1, -2, and -3 proteins that are expressed by different target cell types
- Different from natural cytotoxicity receptor (NCR), NKG2D expression is not confined to NK cells
- It is also expressed on virtually all TCR γ/δ+ and CD8+TCR α/β+ T cells
- NKG2D functions as a triggering receptor involved in natural cytotoxicity mediated by normal NK cells against a variety of tumors or normal target cells
- Importantly, NKG2D can complement the role of NCR in tumor cell lysis
- Remarkably, the combined maskings of NCR and NKG2D can reportedly lead to a complete inhibition of NK-mediated lysis of all tumor or normal cells
- The 1D11 antibody can reportedly block or stimulate the function of NKG2D-positive cells.