BDB562078
Stat6 (pY641) Mouse anti-Human, PE, Clone: 18/P-STAT6, BD
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB562078-Each-of-1 | In Stock | ₹ 1,27,270.00 |
BDB562078 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 1,27,270.00
GST (18%): ₹ 22,908.60
Total Price: ₹ 1,50,178.60
Antigen
Stat6 (pY641)
Classification
Monoclonal
Conjugate
PE
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Phosphorylated Human Stat6 (pY641)
Quantity
250 Tests
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
18/P-STAT6
Description
Signal transducer and activator of transcription 6; IL-4 Stat
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG2a
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Description
- Interleukin-4 (IL-4), a major immunoregulatory cytokine, is secreted by activated T lymphocytes, basophils, and mast cells and plays an important role in modulating T helper cell lineage development
- It induces specific gene expression via the tyrosine phosphorylation of Stat6 at tyrosine 641 (Y641)
- Stat6, a member of the s ignal t ransducers and a ctivators of transcription protein family, mediates signals for IL-4 and, possibly, IL-13
- While Stat6 is widely expressed in human tissues, it exhibits elevated expression in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta
- Following cytokine receptor ligation, Jak kinases are activated and phosphorylate the cytoplasmic tails of the oligomerized receptors
- The SH3:SH2 domain of Stat6 associates with tyrosine-phosphorylated IL-4 receptor and the proximal Jak kinase phosphorylates Stat6 at Y641 on the C-terminal side of the SH2 domain
- Stat6 is then released from the receptor, dimerizes, and is thought to contact the basal transcription machinery by binding to p300/CBP
- Thus, Stat6 mediates the IL-4 signal and is essential for the proper development of adaptive immunity.