BDB562341
GARP Mouse anti-Human, APC, Clone: 7B11 (also known as CMSSC-7B11), BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB562341-Each-of-1 | In Stock | ₹ 40,228.00 |
BDB562341 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,228.00
GST (18%): ₹ 7,241.04
Total Price: ₹ 47,469.04
Antigen
GARP
Classification
Monoclonal
Conjugate
APC
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Recombinant Human LRRC32
Quantity
100 Tests
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
7B11 (also known as CMSSC-7B11)
Description
LRRC32; Garpin; Glycoprotein A repetitions predominant
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG2b κ
Related Products
Description
- The 7B11 (also known as CMSSC-7B11) monoclonal antibody specifically binds to human GARP (Glycoprotein A repetitions predominant)
- The LRRC32 (Leucine rich repeat containing 32) gene encodes the 662 amino acid-residue, 80 kDa transmembrane GARP glycoprotein that has an extracellular region composed primarily of 20 leucine-rich repeats
- GARP is specifically expressed on Treg cells activated through the T cell receptor (TCR)
- Ectopic expression of GARP in human naοve T cells inhibited their proliferation and cytokine secretion upon TCR activation
- Remarkably, GARP over-expression in naοve T cells induced expression of FoxP3 and endowed them with a partial suppressive function
- The extracellular, but not the cytoplasmic region, of GARP was necessary for these functions
- GARP serves as a receptor for latent TGF-beta which may play a role in the suppressive action of Treg cells
- GARP is also expressed on platelets and other tissues, however the function on these cells is not known.