BDB562472
MAPKAPK-2 Mouse, Alexa Fluor 647, Clone: P24-694, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB562472-Each-of-1 | In Stock | ₹ 33,464.00 |
BDB562472 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 33,464.00
GST (18%): ₹ 6,023.52
Total Price: ₹ 39,487.52
Antigen
MAPKAPK-2
Classification
Monoclonal
Conjugate
Alexa Fluor 647
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Phosphorylated human MAPKAPK-2 peptide
Quantity
50 Tests
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
P24-694
Description
MAP kinase-activated protein kinase 2, MAPKAP kinase 2; MK2; MAPK2
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human, Mouse
Isotype
IgG1 κ
Related Products
Description
- Description The P24-694 monoclonal antibody specifically binds to the phosphorylated T334 site (pT334) of MAPKAPK-2
- MAPKAPK-2 is a serine/threonine protein kinase
- This ∽49 kDa member of the MAPKAPK family of protein kinases is also known as mitogen-activated protein kinase-activated protein kinase 2
- MAPKAPK-2 is phosphorylated and activated by p38 MAP kinase in response to stress, cytokines and chemokines
- MAPKAPK-2 is phosphorylated on multiple sites including Thr222, Ser272 and Thr334
- Phosphorylation of any two of these three amino acid residues seems to be required for the activation of this kinase thatserves multiple cellular functions
- Phosphorylation of Thr334 was reported to be essential for nuclear export of the heterodimer formed between p38 MAPK and MAPKAPK-2
- Mice deficient in MAPKAPK-2 have been shown to be protected from ischemic injury
- MAPKAPK-2 is also reported to serve as a cell cycle checkpoint kinase in response to UV irradiation
- The heat shock protein, HSP27 was shown to be one of the major substrates of MAPK and MAPKAPK-2.