BDB562479
EZH2 Mouse, Alexa Fluor 488, Clone: 11/EZH2, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB562479-Each-of-1 | In Stock | ₹ 25,409.50 |
BDB562479 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,409.50
GST (18%): ₹ 4,573.71
Total Price: ₹ 29,983.21
Antigen
EZH2
Classification
Monoclonal
Conjugate
Alexa Fluor 488
Formulation
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Immunogen
Human EZH2 recombinant protein aa. 156-256
Quantity
50 Tests
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
11/EZH2
Description
Enhancer of zeste 2; ENX-1; Histone-lysine N-methyltransferase EZH2; KMT6
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Canine, Chicken, Human, Mouse, Rat
Isotype
IgG1
Related Products
Description
- The 11/EZH2 monoclonal antibody specifically binds to the methyltransferase, EZH2 (Enhancer of Zeste Homolog 2)
- EZH2 is a human homologue of Drosophila's Enhancer of zeste gene, an important regulator of homeobox gene expression
- The EZH2 protein has a predicted molecular weight of ∽85 kDa
- EZH2 is a member of the Polycomb group (PcG) of proteins that are essential for the maintenance, but not initiation, of the transcriptionally repressed state of certain developmental genes
- PcG proteins are a structurally diverse group of proteins with conserved functions from fly to human cells
- PcG family proteins form multimeric complexes that regulate the expression of genes involved in cell cycle, DNA repair and differentiation
- Specifically, EZH2 is a core enzymatic component of PRC2 (polycomb repressive complex 2)
- EZH2 is expressed in some lymph node follicular T cells and B cells
- Thymocytes differentially express EZH2 at various stages during T-cell maturation
- EZH2 interacts with multiple signaling proteins, including Vav, that are involved in lymphocyte development and activation
- It is highly expressed in a variety of tumors including lymphomas as well as breast and prostate cancers
- EZH2 is important in the self renewal and proliferation of numerous stem cell types including fetal hematopoietic stem cells, muscle satellite cells, hepatic stem/progenitor cells, neural stem cells, basal cell progenitors in the developing epidermis, embryonic stem cells, and some cancer stem cells.