BDB562825
CD23 Rat anti-Mouse, PE-Cy7, Clone: B3B4, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB562825-Each-of-1 | In Stock | ₹ 24,208.00 |
BDB562825 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 24,208.00
GST (18%): ₹ 4,357.44
Total Price: ₹ 28,565.44
Antigen
CD23
Classification
Monoclonal
Concentration
0.2mg/mL
Description
FcεRII; Fc-epsilon-RII; Fcer2a; Ly-42; Low-affinity IgE receptor; Fcer2
Immunogen
FcεR isolated from the mouse B hybridoma line O1.2B2
Quantity
0.1 mg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
B3B4
Conjugate
PE-Cyanine7
Host Species
Rat
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Mouse
Isotype
IgG2a κ
Related Products
Description
- The B3B4 antibody reacts with CD23, the low affinity IgE Fc receptor (FcεRII) expressed on mature resting conventional B lymphocytes, but not on B-1 cells (CD5+ B cells) or T lymphocytes
- It does not react with high-affinity IgE receptors, as demonstrated on mouse mast cell lines
- The regulation of CD23 surface expression on activated B cells appears to be complex, depending upon the mode of activation and the presence of cytokines
- IgE synthesis is negatively regulated by CD23, and CD23 expression is upregulated on splenocytes in the presence of IgE
- CD23 is also upregulated on follicular dendritic cells in the lymph nodes of immunized mice, and a subset of splenic dendritic cells expresses CD23
- The B3B4 antibody abrogates antigen-specific IgE-dependent modulation of immune responses in normal mice
- This monoclonal antibody also blocks IgE binding and eosinophil infiltration in the lung of immunized mice
- Different in vivo results have been obtained when using the intact B3B4 antibody or the F(ab')2 fragments
- B3B4 mAb does not cross-react with rat or human IgE Fc Receptor.