CD200 Mouse anti-Human, Brilliant Violet 605, Clone: MRC OX-104, BD

Description

• The MRC OX-104 monoclonal antibody specifically binds to CD200
• CD200 is a 40-45 kDa type 1 transmembrane glycoprotein and is also referred to as OX2
• CD200 is a member of the immunoglobulin superfamily of proteins
• It contains two Ig domains, a single transmembrane region and a short cytoplasmic tail
• CD200 is expressed on resting and PMA-activated T- and B-cells, but not on NK cells, monocytes, granulocytes, or platelets
• It has been found on a subset of CD34+ progenitor cells
• Interaction of CD200 with its receptor on macrophages induces a downregulation of macrophage activity in a variety of tissues, suggesting a regulatory function
• This antibody is conjugated to BD Horizon BV605 which is part of the BD Horizon Brilliant™ Violet family of dyes
• With an Ex Max of 407-nm and Em Max of 602-nm, BD Horizon BV605 can be excited by a violet laser and detected with a standard 610/20-nm filter set
• BD Horizon BV605 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an Em max at 605-nm
• Due to the excitation of the acceptor dye by the green (532 nm) and yellow-green (561 nm) lasers, there will be significant spillover into the PE and BD Horizon PE-CF594 detectors off the green or yellow-green lasers
• BD Horizon BV605 conjugates are very bright, often exhibiting brightness equivalent to PE conjugates and can be used as a third color off of the violet laser.