BDB562912
Lgr5 (Central LRR) Rat anti-Human, Alexa Fluor 647, Clone: 4D11F8, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB562912-Each-of-1 | In Stock | ₹ 25,276.00 |
BDB562912 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,276.00
GST (18%): ₹ 4,549.68
Total Price: ₹ 29,825.68
Antigen
Lgr5 (Central LRR)
Classification
Monoclonal
Conjugate
Alexa Fluor 647
Formulation
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Immunogen
Human LGR5 DNA
Quantity
50 Tests
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
4D11F8
Description
GPR49, GPR67, HG38
Host Species
Rat
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG2b λ
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Description
- Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) is a seven transmembrane-domain receptor that is a target gene for Wnt and marks stem cells in the small intestine, colon, stomach, and hair follicle
- Lgr5 was initially identified as a potential stem cell marker due to restricted expression of Lgr5 in the intestinal crypt and labeling of rapidly cycling cells of the colon and intestine
- Using both lineage tracing and organoid culture experiments, Lgr5 positive cells are capable of generating all types of the small intestine epithelium hence indicating that Lgr5 marks stem cells of the small intestine and colon
- R-spondin growth factors, which are secreted agonists of the Wnt pathway, bind Lgr5
- The binding of R-spondins to Lgr5 leads to recruitment of the Frizzled/LRP Wnt receptor complex, which binds to Wnt ligands and leads to downstream Wnt signaling
- Lgr5 is up-regulated in colon and ovarian cancers and has been implicated in promotion of tumor growth and metastasis
- The 4D11F8 monoclonal antibody recognizes an epitope in the center of the leucine-rich repeat (LRR) region of Human Lgr5
- Host Species: Rat Clone: 4D11F8 Isotype: IgG2b, λ Species Reactivity: Hu Immunogen: Human LGR5 DNA Flow Cytometry