Home Products Antibodies Primary Antibodies BDB563090
BDB563090

CD27 Mouse anti-Human, Brilliant Violet 510, Clone: L128, BD

Manufacturer: Fischer Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 BDB563090-Each-of-1 In Stock ₹ 18,156.00

BDB563090 - Each of 1

₹ 18,156.00

In Stock

Quantity

1

Base Price: ₹ 18,156.00

GST (18%): ₹ 3,268.08

Total Price: ₹ 21,424.08

Antigen

CD27

Classification

Monoclonal

Conjugate

Brilliant Violet 510

Formulation

Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

Immunogen

Human Activated Peripheral Blood Cells

Quantity

25 Tests

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Applications

Flow Cytometry

Clone

L128

Description

TNFRSF7; Tumor necrosis factor receptor superfamily, member 7; Tp55; S152

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Target Species

Human

Isotype

IgG1

Description

  • The L128 monoclonal antibody specifically binds to human CD27
  • CD27 is a 55-kDa disulfide-linked dimer that is a member of the nerve growth factor (NGF) super family
  • This family also includes CD40, rat OX40, tumor necrosis factor (TNF) receptors and CD95 (Fas)
  • With its ligand CD70, CD27 acts in a co-stimulatory fashion on T lymphocytes
  • Present on most peripheral blood T lymphocytes and medullary thymocytes, the CD27 antigen is upregulated upon activation with the release of a soluble form, 28 to 32 kDa
  • It is also detected on a subpopulation of approximately 33% of circulating B lymphocytes
  • Following exposure to antigens, CD45RA+ T lymphocytes respond by upregulating the CD27 antigen
  • After maximal stimulation, the CD27 antigen cannot be re-expressed on long-term cultures or on CD45RA-CD27+ T lymphocytes
  • The CD4+CD27- population is contained within the memory CD45RO+ subset that proliferates after exposure to allergens
  • Two subpopulations of B lymphocytes bearing the CD27 antigen secrete IgM (δ+) and IgG (δ-).