BDB563149
TSLP Receptor Mouse anti-Human, PE, Clone: 1F11/TSLPR, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB563149-Each-of-1 | In Stock | ₹ 25,409.50 |
BDB563149 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,409.50
GST (18%): ₹ 4,573.71
Total Price: ₹ 29,983.21
Antigen
TSLP Receptor
Classification
Monoclonal
Concentration
0.2mg/mL
Description
CRL2; CRLF2; CRLF2Y; Cytokine receptor-like factor 2; IL-XR; TSLPR
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG1 κ
Applications
Flow Cytometry
Clone
1F11/TSLPR
Conjugate
PE
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
Human TSLP Receptor Transfected Cell Line
Quantity
50 μg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Related Products
Description
- The 1F11/TSLPR monoclonal antibody specifically binds to Thymic Stromal Lymphopoietin Receptor (TSLPR)
- TSLPR is a member of the hematopoietin receptor superfamily and is also known as Cytokine Receptor-like Factor 2 (CRL2, CRLF2Y, CRLF2)
- The functional TSLPR complex consists of two subunits, TSLPR and the alpha subunit of the Interleukin-7 Receptor (IL-7Rα)
- Analysis of the TSLPR reveals sequence similarity with the common cytokine receptor gamma chain (γc; CD132)
- Functional TSLPRs are expressed by epithelial cells and a variety of hematopoietic cell types, including thymocytes, T cells, B cells, natural killer T cells, monocytes, macrophages, basophils, and dendritic cells (DC)
- Recent studies indicate that TSLP can activate multiple STAT (Signal Transducer and Activator of Transcription) signaling proteins
- TSLP enhances the maturation and viability of DC
- It strongly induces DC expression of the CD40 and CD80 costimulatory molecules and chemokines, e.g., TARC (Thymus and activation-regulated chemokine; CCL17) that can attract Th2 effector cells
- TSLP supports B cell development
- TSLP costimulates the proliferation of naοve T cells in the presence of mature DC
- TSLP is also able to increase the sensitivity of T cell receptor-activated CD4+ T cells to low doses of IL-2
- In the presence of TSLP, the acute myeloid leukemia-derived cell line, MUTZ-3, shows induced growth and reduced apoptosis
- CRLF2 deregulated gene expression is thought to be involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia
- The 1F11/TSLPR antibody is reportedly a neutralizing antibody.