BDB563421
Notch1 Mouse anti-Human, PE, Clone: MHN1-519, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB563421-Each-of-1 | In Stock | ₹ 21,627.00 |
BDB563421 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 21,627.00
GST (18%): ₹ 3,892.86
Total Price: ₹ 25,519.86
Antigen
Notch1
Classification
Monoclonal
Conjugate
PE
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Human Notch1 Recombinant Protein
Quantity
50 Tests
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
MHN1-519
Description
NOTCH1; Notch 1; NOTC1; hN1; TAN1; Neurogenic locus notch homolog protein 1
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG1 κ
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Description
- Description The MHN1-519 monoclonal antibody specifically binds to an extracellular domain of human Notch1
- Notch1 is a type 1 transmembrane glycoprotein receptor and member of the Notch family that includes Notch1-Notch4
- Notch1 is cleaved in the Golgi and presents as a cell surface heterodimeric receptor
- The Notch1 receptor can bind to several membrane-bound ligands including Jagged1, Jagged2, Delta1 and Delta4
- Upon ligand binding, Notch1 undergoes proteolytic cleavage that results in the release of the Notch intracellular domain, NICD
- NICD translocates to the nucleus where it forms a transcriptional activator complex with various transcriptional factors
- These multimeric complexes either positively or negatively regulate the expression of multiple genes including those that orchestrate many facets of embryonic development and the subsequent functioning of multiple organ systems such as the immune, cardiovascular and nervous systems
- Within the immune system, Notch signaling significantly affects the development, proliferation, differentiation and survival of numerous cell types including thymocytes and subsets of T and B lymphocytes and dendritic cells
- In altered forms, Notch1 has been associated with certain cardiovascular diseases and with some lymphocyte neoplasms.