BDB563489
mTOR (pS2448) Mouse, PE, Clone: O21-404, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB563489-Each-of-1 | In Stock | ₹ 28,257.50 |
BDB563489 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 28,257.50
GST (18%): ₹ 5,086.35
Total Price: ₹ 33,343.85
Antigen
mTOR (pS2448)
Classification
Monoclonal
Conjugate
PE
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Phosphorylated Peptide
Quantity
50 Tests
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
O21-404
Description
Mammalian target of rapamycin; FRAP1; RAFT1; RAPT1
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human, Mouse, Rat
Isotype
IgG1 κ
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Description
- Description The O21-404 monoclonal antibody recognizes the human mammalian target of rapmycin,(mTOR) that is phosphorylated at serine residue 2448, mTOR (pS2448)
- mTOR belongs to the phosphoinositide-3-kinase (PI3K)-related (PIKK) family of kinases
- mTOR is also known as mechanistic target of rapamycin (serine/threonine kinase), FRAP, RAFT1, and RAPT1
- mTOR functions as an amino acid and ATP sensor to balance nutrient availability and cell growth
- When nutrients are sufficiently available, mTOR is activated by phosphorylation at serine residue 2448 through the PI3 kinase/Akt signaling pathway
- Phosphorylated mTOR in turn activates the p70 S6 kinase and contributes to the inactivation 4E-BP1, an elF4E inhibitor
- In this way, mTOR participates in the upregulation of cellular protein synthesis, growth, proliferation and survival
- mTOR function may be abnormally regulated in tumors.