BDB563588
CD154 Mouse anti-Human, APC-Cy7, Clone: TRAP1, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB563588-Each-of-1 | In Stock | ₹ 32,707.50 |
BDB563588 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 32,707.50
GST (18%): ₹ 5,887.35
Total Price: ₹ 38,594.85
Antigen
CD154
Classification
Monoclonal
Conjugate
APC-Cyanine7
Formulation
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Baboon, Cynomolgus, Human, Rhesus Monkey
Isotype
IgG1 κ
Applications
Flow Cytometry
Clone
TRAP1
Description
CD40LG; CD40 ligand; CD40L; TNFSF5; T-BAM; TRAP
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Related Products
Description
- The TRAP1 monoclonal antibody specifically binds to CD154
- CD154 is a 39 kDa type II membrane glycoprotein that is a member of the tumor necrosis factor superfamily, Tumor necrosis factor ligand superfamily member 5 (TNFSF5)
- CD154 is expressed on a variety of cell types including activated CD4+ T cells and some CD8+ T cells, NK cells, mast cells and basophils
- CD154 is also known as CD40 ligand (CD40L); it serves as a ligand for CD40 that is expressed on B cells, macrophages, and dendritic cells
- The expression of CD154 by activated T-helper cells costimulates B-cell activation and proliferation through binding to CD40 expressed on B cells
- In response to T-dependent antigens, the CD154 and CD40 interaction is required for B-lymphocyte differentiation, including immunoglobulin production and isotype switching and memory B cell generation
- The TRAP1 antibody can partially block T cell-B cell interaction and inhibit the subsequent proliferation, differentiation, and memory formation of B cells
- It has been reported that patients with X-linked hyper-IgM syndrome have defective expression of functional CD154 due to mutations in the CD40LG gene that encodes CD154.