BDB563801
Helios Armenian Hamster , PE, Clone: 22F6, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB563801-Each-of-1 | In Stock | ₹ 25,409.50 |
BDB563801 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,409.50
GST (18%): ₹ 4,573.71
Total Price: ₹ 29,983.21
Antigen
Helios
Classification
Monoclonal
Concentration
0.2mg/mL
Description
IKAROS family zinc finger protein 2; ANF1A2; HELIOS; ZNF1A2; ZNFN1A2
Host Species
Armenian Hamster
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human, Mouse
Isotype
IgG
Applications
Flow Cytometry
Clone
22F6
Conjugate
PE
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
Mouse Helios Peptide
Quantity
50 μg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Related Products
Description
- The 22F6 monoclonal antibody specifically binds to mouse and human Helios
- Helios is a member of the Ikaros family of zinc-finger transcription factors, which play important roles in hematopoietic cell development and tumor suppression
- Helios expression is restricted to the earliest stages of embryonic hematopoiesis, a variety of epithelial tissues and is notably increased in thymic-derived regulatory CD4+Foxp3+ T (Treg) cells
- Its high expression levels in Treg cells are independent from Foxp3 and are believed to contribute, along with other transcription factors, to the phenotypic stability of natural regulatory T cells
- Accordingly, it has been demonstrated that Helios directly stimulates Foxp3 transcription while it inhibits ll2 gene expression, contributing for the maintenance of cellular anergy
- Helios is also differentially expressed during negative and positive selection in the thymus, marking CD4+ autoreactive cells for deletion
- Helios may possibly play roles in T cell activation, since it is upregulated in Th2 and Tfh cells
- Despite these roles in T cell development and function, Helios genetic ablation in mice revealed no significant abnormalities in Treg or other T cell subsets
- This finding suggests that other Ikaros family members may play redundant roles.