BDB564797
CD226 Mouse anti-Human, Alexa Fluor 647, Clone: DX11, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB564797-Each-of-1 | In Stock | ₹ 27,011.50 |
BDB564797 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 27,011.50
GST (18%): ₹ 4,862.07
Total Price: ₹ 31,873.57
Antigen
CD226
Classification
Monoclonal
Conjugate
Alexa Fluor 647
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide
Immunogen
Human CTL Clone
Quantity
100 Tests
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
DX11
Description
DNAM-1; DNAM1; PTA1; PTA-1; TLiSA1
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG1 κ
Related Products
Description
- The DX11 monoclonal antibody specifically binds to CD226 which is also known as DNAX accessory molecule-1 (DNAM-1), Platelet and T cell activation antigen 1 (PTA1), or T lineage-specific activation antigen 1 antigen (TLiSA1)
- CD226 is a 65 kDa type 1 transmembrane glycoprotein consisting of 318 amino acid residues including two Ig-like domains
- CD226 is expressed on the majority of T cells, NK cells, monocytes, platelets, and a subset of B cells, but not on granulocytes or erythrocytes
- It is also present on a subset of thymocytes coexpressing high density surface CD3
- CD226 is not present on normal fibroblast cell lines or tumor cell lines of epithelial or neuronal origins
- CD226 is a tyrosine phosphorylated, signal-transducing molecule which participates in primary adhesion during cytotoxic T lymphocyte (CTL)- or NK cell-mediated cytotoxicity
- The DX11 antibody inhibits T- and NK cell-mediated cytotoxicity against a variety of tumor cell targets, and blocks cytokine production by alloantigen-specific T cells.