BDB564814
RUNX3 Mouse, PE, Clone: R3-5G4, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB564814-Each-of-1 | In Stock | ₹ 21,983.00 |
BDB564814 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 21,983.00
GST (18%): ₹ 3,956.94
Total Price: ₹ 25,939.94
Antigen
RUNX3
Classification
Monoclonal
Conjugate
PE
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Human RUNX3 Recombinant Protein
Quantity
50 Tests
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
R3-5G4
Description
AML2; AML-2; CBFA3; PEBP2aC; PEBP2A3
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human, Mouse
Isotype
IgG1 κ
Related Products
Description
- The R3-5G4 monoclonal antibody specifically binds to Runt-related transcription factor 3 (RUNX3) which is also known as Acute myeloid leukemia 2 protein (AML2), Core-binding factor subunit alpha-3 (CBFA3), and Polyomavirus enhancer-binding protein 2 alpha C subunit (PEBP2aC)
- RUNX3 is a member of the RUNX transcription factor family which includes RUNX1-3
- RUNX3 is a key regulator of gene expression related to the development and differentiation of cells within the nervous and immune systems
- In the immune system, RUNX3 is particularly involved in the commitment of CD8+ T cells in the thymus
- RUNX3 is highly expressed and essential for the cytotoxic functions of NK cells, peripheral CD8+T cells and CD4+ CD8αα intraepithelial lymphocytes in the gut
- RUNX3 als o plays a role in the differentiation and effector functions of Th1 cells
- RUNX3 is activated downstream of the TGF-β signaling pathway and can play a role in tumor suppression
- Aberrant expression of RUNX3 has been associated with tumorigenesis including the development of gastric and other cancers.