Home Products Antibodies Primary Antibodies BDB565474
BDB565474

TIGIT Mouse anti-Mouse, APC-R700, Clone: 1G9, BD

Manufacturer: BD Biosciences

Select a Size

Pack Size SKU Availability Price
Each of 1 BDB565474-Each-of-1 In Stock ₹ 23,451.50

BDB565474 - Each of 1

₹ 23,451.50

In Stock

Quantity

1

Base Price: ₹ 23,451.50

GST (18%): ₹ 4,221.27

Total Price: ₹ 27,672.77

Antigen

TIGIT

Classification

Monoclonal

Concentration

0.2mg/mL

Description

Tigit; Vstm3; T cell immunoreceptor with Ig and ITIM domains

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Target Species

Mouse

Isotype

IgG1 κ

Applications

Flow Cytometry

Clone

1G9

Conjugate

APC-R700

Formulation

Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.

Immunogen

Mouse TIGIT Recombinant Protein

Quantity

50 μg

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Description

  • The 1G9 monoclonal antibody specifically binds to T cell immunoreceptor with Ig and ITIM domains (TIGIT) which is also known as, V-set and transmembrane domain-containing protein 3 (Vstm3)
  • TIGIT is a 26 kDa, type I transmembrane glycoprotein that belongs to the poliovirus receptor (PVR) family
  • TIGIT is expressed on activated and memory CD4+ T cells and CD8+ T cells, follicular T helper cells, regulatory T cells, and NK cells
  • Its ligands include the poliovirus receptor (PVR, aka, CD155), poliovirus receptor-related protein 2 (PVRL2, aka, CD112), and poliovirus receptor-related protein 3 (PVRL3, CD113)
  • TIGIT functions as a negative regulator of T cell and NK cell responses including proliferation, cytotoxicity, and the production of proinflammatory cytokines
  • TIGIT-deficient mice are reportedly more susceptible to developing autoimmune diseases in certain model systems
  • This antibody was conjugated to BD Horizon APC-R700, which has been developed exclusively by BD Biosciences as a better alternative to Alexa Fluor™ 700
  • APC-R700 excites and emits at similar wavelengths to Alexa Fluor™ 700 yet exhibits significantly improved brightness
  • This dye can be excited by the red laser and detected with the same filter set as Alexa Fluor™ (eg, 730/45-nm filter).