Granzyme B Mouse anti-Human, RB545, Clone: GB11, BD Horizon™
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB569291-Each-of-1 | In Stock | ₹ 15,014.30 |
BDB569291 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 15,014.30
GST (18%): ₹ 2,702.574
Total Price: ₹ 17,716.874
Antigen
Granzyme B
Classification
Monoclonal
Conjugate
RB545
Gene Alias
GZMB; Granzyme-2; CCPI; CGL1; CSPB; CTLA1; CTSGL1; GRB; HLP; SECT
Immunogen
Human Granzyme B
Quantity
25 Tests
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Excitation/Emission
Excitation Source: Blue 488 nm, Excitation Max: 496 nm, Emission Max: 545 nm
Applications
Flow Cytometry
Clone
GB11
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Gene ID (Entrez)
3002
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated to the dye under optimum conditions and unreacted dye was removed.
Isotype
IgG1 κ
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Description
- Description The GB11 antibody specifically reacts with human granzyme B, a serine protease of approximately 32 kDa
- Granzyme B is stored in the granules of cytotoxic T lymphocytes and NK cells along with the pore-forming protein perforin
- In the classic model of target cell lysis, perforins create holes in the target cell membrane allowing entrance of granzymes
- Granzyme B has been shown to act on specific substrates including caspase-3, -7, -9, and -10 which in turn give rise to enzymes that mediate apoptosis
- Granzyme B may also be involved in the hydrolysis of extracellular matrix components
- Detectable levels of granzyme B have been detected in sera from healthy volunteers
- The immunogen used to generate the GB11 hybridoma was human granzyme B isolated from an NK cell line
- Granzyme B Monoclonal antibody specifically detects Granzyme B in Human samples
- It is validated for Intracellular Staining (Flow Cytometry)