BDB610610
PKA(RIα) Mouse, Unlabeled, Clone: 20, BD
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB610610-Each-of-1 | In Stock | ₹ 47,036.50 |
BDB610610 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,036.50
GST (18%): ₹ 8,466.57
Total Price: ₹ 55,503.07
Antigen
PKA(RIα)
Classification
Monoclonal
Concentration
250μg/mL
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen
Human PKA [RIα] aa. 1-381
Quantity
150 μg
Research Discipline
Cell Biology
Target Species
Canine, Chicken, Human, Mouse, Rat
Isotype
IgG1
Applications
Western Blot
Clone
20
Conjugate
Unconjugated
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
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Description
- cAMP-dependent Protein Kinase (PKA) is composed of two distinct subunits: catalytic (C) and regulatory (R)
- Four regulatory subunits have been identified: RIα, RIβ, RIIα, and RIIβ
- These subunits define type I and II cAMP-dependent protein kinases
- Following binding of cAMP, the regulatory subunits dissociate from the catalytic subunits, rendering the enzyme active
- Type I and type II holoenzymes have three potential C subunits (Cα, Cβ, or Cγ)
- Type II PKA can be distinguished by autophosphorylation of the R-subunits, while type I PKA binds Mg/ATP with high affinity
- Most cells express both type I and type II PKAs
- Although the Rα isoforms are ubiquitously expressed, the Rβ isoforms are predominant in nervous and adipose tissues
- Expression of the RIβ subunit is modulated during muscle and adipocyte differentiation in vitro
- Immunofluorescence, Immunoprecipitation, Western Blotting