BDB610878
SHC Mouse, Unlabeled, Clone: 30, BD
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB610878-Each-of-1 | In Stock | ₹ 25,053.50 |
BDB610878 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,053.50
GST (18%): ₹ 4,509.63
Total Price: ₹ 29,563.13
Antigen
SHC
Classification
Monoclonal
Concentration
250μg/mL
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen
Human SHC aa. 359-473
Quantity
50 μg
Research Discipline
Cell Biology
Target Species
Canine, Chicken, Human, Mouse, Rat
Isotype
IgG1
Applications
Western Blot
Clone
30
Conjugate
Unconjugated
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
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Description
- The mammalian SHC proteins, which are expressed as multiple isoforms (46, 52, and 66kDa), each contain a C-terminal SH2 domain and an N-terminal glycine/proline rich sequence
- These proteins function as early signaling intermediates (also called adaptor proteins) which relay G protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK)-induced signals via the Ras transduction pathway
- To this end, the SHC proteins contain specific tyrosine residues which are phosphorylated following association with the active RTKs
- Phosphorylated SHC forms a complex with the adaptor protein GRB2
- Association of the SHC-GRB2 complex with the Ras guanine nucleotide exchange factor (Ras-GEF) mediates the localization of Ras-GEF to the plasma membrane
- Once at the plasma membrane, Ras-GEF activates Ras by catalyzing the Ras-GTP for Ras-GDP exchange
- Over-expression of SHC results in cell transformation, and phosphorylation of SHC correlates with activation of the ERK1/ERK2 kinases
- The SHC proteins are mediators of signals that are essential for cell metabolism, growth, and differentiation
- Immunofluorescence, Western Blotting