BDB610938
IAK1 Mouse, Unlabeled, Clone: 4, BD
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB610938-Each-of-1 | In Stock | ₹ 25,454.00 |
BDB610938 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,454.00
GST (18%): ₹ 4,581.72
Total Price: ₹ 30,035.72
Antigen
IAK1
Classification
Monoclonal
Concentration
250μg/mL
Description
Aurora-A Kinase
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
Applications
Western Blot
Clone
4
Conjugate
Unconjugated
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen
Mouse IAK1 aa. 8-116
Quantity
50 μg
Research Discipline
Cell Biology
Target Species
Human, Mouse, Rat
Isotype
IgG1
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Description
- Cell division is a tightly regulated process that ensures the segregation of chromosomes into daughter cells
- Essential to this regulation is the modification of cell cycle components by reversible phosphorylation
- Ipl1 and aurora are two related kinases isolated from S.cerevisiae and Drosophila, respectively
- Inactivation of these kinases results in abnormal chromosome segregation and disruption of the centrosome
- A structurally and functionally similar kinase, IAK1 (Ipl1- and Aurora-related kinase 1), is a regulator of mammalian chromosome segregation
- Although IAK1 may be present in the cytoplasm, it is detected on the centrosome following duplication and also associates with the spindle microtubules from metaphase through cell division
- Expression of IAK1 is stringently regulated during the cell cycle
- Both mRNA and protein are initially expressed in S-phase, are elevated during M-phase, and are undetectable following completion of mitosis
- Increasing evidence suggests that IAK1 belongs to a novel subfamily of the ser/thr kinase superfamily
- Although mutational analysis of IAK1 will directly determine its function, it appears to be a key player in the control of cell division
- Immunofluorescence, Western Blotting