G3BP Mouse anti-Human, Unlabeled, Clone: 23, BD

Description

• The Ras proteins are low molecular weight GTPases that play a critical role in the control of proliferation, differentiation, and cytoskeletal organization
• RasGAP acts as a negative regulator of Ras, as well as a downstream target of Ras
• It participates in the signal transduction cascade through interactions with other signaling proteins
• Via its C-terminal domain, RasGAP interacts with Ras, but the N-terminus interacts with other signaling molecules such as p62 and p190
• This function of RasGAP is mediated by the presence of SH2, SH3, and PH domains in the N-terminal region
• However, some signaling proteins cannot bind to these domains
• In an attempt to identify RasGAP-interacting molecules, a GAP SH3-Binding Protein (G3BP) was identified
• This protein exhibits sequence homology to the hnRNP superfamily
• It contains RNP1 and RNP2 motifs and is found primarily in the cytosol
• G3BP interacts with GAP in proliferating cells and is dependent on the activation state of Ras
• In addition, G3BP contains an intrinsic endonuclease activity that cleaves 3′-untranslated region (3′-UTR) mRNA
• These data indicate that G3BP may link the Ras pathway to mRNA degradation
• Host Species: Mouse Clone: 23 Isotype: IgG1 Species Reactivity: Human Immunogen: Human G3BP aa
• 210-323 Formula Weight [Chemical]: 55-70kDa Immunofluorescence, Western Blotting