BDB612111
BAF47 Mouse, Unlabeled, Clone: 25, BD
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB612111-Each-of-1 | In Stock | ₹ 51,130.50 |
BDB612111 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 51,130.50
GST (18%): ₹ 9,203.49
Total Price: ₹ 60,333.99
Antigen
BAF47
Classification
Monoclonal
Concentration
250μg/mL
Description
SNF5
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
Applications
Western Blot
Clone
25
Conjugate
Unconjugated
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen
Mouse BAF47 aa. 257-359
Quantity
150 μg
Research Discipline
Cell Biology
Target Species
Human, Mouse, Rat
Isotype
IgG2a
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Description
- SWI/SNF complexes facilitate gene activation and transcription factor binding by altering repressive chromatin structures in an ATP-dependent manner
- In mammals, SWI/SNF complexes are present in mutliple forms that include 9-12 BRG1-associated factors (BAFs) per complex
- These BAF proteins range in molecular weight from 47 to 250kDa
- BAF47/SNF5 (SMARCB1/Ini1) complexes with BRG1- and BRM-containing SWI/SNF complexes
- BAF47/SNF5 mRNA is widely expressed in cell lines and tissues, and BAF47/SNF5 gene is mutated in many human tumors
- The latter is indicative of a tumor suppressor role for BAF47/SNF5
- In addition, mice deficient for BAF47 die early in embryogenesis, while BAF47/SNF5 heterozygous mice display a variety of tumors in the soft tissues of the head and neck
- BAF47/SNF5 also binds the HIV-1 integrase and stimulates integrase-mediated DNA joining activity
- Thus, BAF47/SNF5 is a component of SWI/SNF complexes that may be critical for normal development and tumor suppression, but may also be a protein utilized for viral DNA integration into host DNA
- Western Blotting