BDB612136
Calreticulin Mouse, Unlabeled, Clone: 16, BD
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB612136-Each-of-1 | In Stock | ₹ 25,454.00 |
BDB612136 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,454.00
GST (18%): ₹ 4,581.72
Total Price: ₹ 30,035.72
Antigen
Calreticulin
Classification
Monoclonal
Concentration
250μg/mL
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen
Mouse Calreticulin aa. 270-390
Quantity
50 μg
Research Discipline
Cell Biology
Target Species
Human, Mouse, Rat
Isotype
IgG1
Applications
Western Blot
Clone
16
Conjugate
Unconjugated
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
Related Products
Description
- Proteins undergo numerous modifications, including folding, translocation, and degradation
- During such modifications, polypeptides are rarely in a native, stable state
- Molecular chaperones are a diverse group of proteins that modulate polypeptide stability through ATP-dependent folding
- Many chaperone proteins are found in the endoplasmic reticulum (ER)
- Calreticulin is a luminal ER protein that is 39% homologous to the ER chaperone protein, calnexin
- Calreticulin contains a C-terminal KDEL ER retention signal, and can bind Ca 2+ ;, Zn 2+ , ATP, and the proteins, ERp57 and protein disulfide isomerase
- The molecular chaperone activities of calreticulin may include folding of both Asn-linked glycoproteins and non-glycosylated proteins
- In addition, calreticulin is a component of MHC I/transporter associated with Ag presentation (TAP) complex where it may function in peptide assembly onto nascent class I molecules
- Calreticulin may also function in integrin signaling, since it binds a3-integrin subunits and regulates integrin-mediated metalloprotease secretion
- Thus, calreticulin may be involved in Ca 2+ ; storage, cell adhesion, and protein folding
- Immunofluorescence, Western Blotting