BDB612600
Stat6 (pY641) Mouse anti-Human, Alexa Fluor 488, Clone: 18/P-STAT6, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB612600-Each-of-1 | In Stock | ₹ 28,257.50 |
BDB612600 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 28,257.50
GST (18%): ₹ 5,086.35
Total Price: ₹ 33,343.85
Antigen
Stat6 (pY641)
Classification
Monoclonal
Conjugate
Alexa Fluor 488
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
18/P-STAT6
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Phosphorylated Human Stat6 (pY641)
Quantity
50 Tests
Research Discipline
Cell Biology
Target Species
Human
Isotype
IgG2a
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Description
- Interleukin-4 (IL-4), a major immunoregulatory cytokine, is secreted by activated T lymphocytes, basophils, and mast cells and plays an important role in modulating T helper cell lineage development
- It induces specific gene expression via the tyrosine phosphorylation of Stat6 at tyrosine 641 (Y641)
- Stat6, a member of the signal transducers and activators of transcription protein family, mediates signals for IL-4 and, possibly, IL-13
- While Stat6 is widely expressed in human tissues, it exhibits elevated expression in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta
- Following cytokine receptor ligation, Jak kinases are activated and phosphorylate the cytoplasmic tails of the oligomerized receptors
- The SH3:SH2 domain of Stat6 associates with tyrosine-phosphorylated IL-4 receptor and the proximal Jak kinase phosphorylates Stat6 at Y641 on the C-terminal side of the SH2 domain
- Stat6 is then released from the receptor, dimerizes, and is thought to contact the basal transcription machinery by binding to p300/CBP
- Thus, Stat6 mediates the IL-4 signal and is essential for the proper development of adaptive immunity
- Flow Cytometry, Intracellular Staining