BDB740587
CD8 Mouse anti-Human, Brilliant Violet 650, Clone: HIT8a, BD Optibuild™
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB740587-Each-of-1 | In Stock | ₹ 49,528.50 |
BDB740587 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,528.50
GST (18%): ₹ 8,915.13
Total Price: ₹ 58,443.63
Antigen
CD8
Classification
Monoclonal
Concentration
0.2mg/mL
Description
CD8α; CD8A; CD8 alpha; Leu2a; MAL; T8; p32
Host Species
Mouse
Quantity
50 μg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
HIT8a
Conjugate
Brilliant Violet 650
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG1 κ
Related Products
Description
- The HIT8a monoclonal antibody specifically binds to CD8a ( CD8α )
- CD8α is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily
- CD8α is expressed by the majority of thymocytes, by subpopulations of αβ T cells and γδ T cells and by some NK cells
- Cell surface CD8α is expressed either as a disulfide-linked homodimer (CD8αα) or as a heterodimer (CD8αβ) when disulfide-bonded to a CD8 beta chain (CD8β)
- CD8-positive αβ T cells coexpress both CD8αα homodimers and CD8αβ heterodimers whereas some γδ T cells and NK cells express CD8αα homodimers
- CD8 plays important roles in T cell activation and selection
- The extracellular IgSF domain of CD8α binds to a non-polymorphic determinant on HLA class I molecules (α3 domain) and enables CD8 to function as a co receptor with MHC class I-restricted TCR during T cell recognition of antigen
- The cytoplasmic domain of CD8α associates with Lck, a Src family protein tyrosine kinase that is involved in intracellular signaling
- Clones HIT8a and RPA-T8 are not cross-blocking.