BDB740706
CD119 Rat anti-Mouse, Brilliant Violet 711, Clone: GR20, BD Optibuild™
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB740706-Each-of-1 | In Stock | ₹ 35,600.00 |
BDB740706 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 35,600.00
GST (18%): ₹ 6,408.00
Total Price: ₹ 42,008.00
Antigen
CD119
Classification
Monoclonal
Concentration
0.2mg/mL
Description
Ifngr1; IFN-γ Receptor α; IFN-gamma R alpha; Ifngr; INF-g Receptor; Cd119
Host Species
Rat
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Mouse
Isotype
IgG2a κ
Applications
Flow Cytometry
Clone
GR20
Conjugate
Brilliant Violet 711
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
BALB/c mouse monomyelocytic cell line WEHI-3
Quantity
50 μg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- The GR20 monoclonal antibody specifically binds to CD119, the α chain of the interferon γ(IFN- γ) receptor
- This receptor is expressed by mouse leukocytes, endothelial, and epithelial cells, but not by mature erythrocytes
- GR20 mAb recognizes an epitope (susceptible to certain fixatives) in the ligand-binding site of the receptor
- It can block the binding of mouse IFN- γ; therefore, it can inhibit IFN- γ.mediated effects including the activation of mouse macrophages for tumor cell killing
- IFN- γhas been reported to induce the expression of Ly-6A/E antigen on cell lines and normal B lymphocytes, and the GR20 antibody is capable of inhibiting the IFN- γ The antibody was conjugated to BD Horizon™ BV711 which is part of the BD Horizon Brilliant™ Violet family of dyes
- This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 711-nm
- BD Horizon BV711 can be excited by the violet laser and detected in a filter used to detect Cy™5.5 / Alexa Fluor™ 700-like dyes (eg, 712/20-nm filter)
- Due to the excitation and emission characteristics of the acceptor dye, there may be moderate spillover into the Alexa Fluor™ 700 and PerCP-Cy5.5 detectors
- However, the spillover can be corrected through compensation as with any other dye combination.