BDB740783

CD62L Mouse anti-Human, Brilliant Violet 711, Clone: DREG-56, BD Optibuild™

Manufacturer: BD Biosciences

Select a Size

Pack Size SKU Availability Price
Each of 1 BDB740783-Each-of-1 In Stock ₹ 49,306.00

BDB740783 - Each of 1

₹ 49,306.00

In Stock

Quantity

1

Base Price: ₹ 49,306.00

GST (18%): ₹ 8,875.08

Total Price: ₹ 58,181.08

Antigen

CD62L

Classification

Monoclonal

Concentration

0.2mg/mL

Description

SELL; L-selectin; LSEL; LAM-1; LECAM-1; LEU8; LNHR; MEL-14; PLNHR; TQ-1

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Target Species

Human

Isotype

IgG1 κ

Applications

Flow Cytometry

Clone

DREG-56

Conjugate

Brilliant Violet 711

Formulation

Aqueous buffered solution containing ≤0.09% sodium azide.

Immunogen

Supernatant from PMA-activated Human Peripheral Blood Leukocytes

Quantity

50 μg

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

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Description

  • The DREG-56 monoclonal antibody specifically binds to CD62L
  • CD62L is a 76-95 kDa glycoprotein that is also referred to as L-selectin or LECAM-1
  • CD62L is expressed on neutrophils, monocytes, T- and B-lymphocyte subsets and NK cells
  • The DREG-56 antibody recognizes the same antigen as LAM-1, and specifically inhibits >90% of binding of human lymphocytes to high endothelial venules (HEV) in frozen sections of peripheral, but not mucosal lymphoid tissue
  • It thus defines L-selectin as a human lymphocyte homing receptor for peripheral lymph node HEV
  • The antibody was conjugated to BD Horizon™ BV711 which is part of the BD Horizon Brilliant™ Violet family of dyes
  • This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 711-nm
  • BD Horizon BV711 can be excited by the violet laser and detected in a filter used to detect Cy™5.5 / Alexa Fluor™ 700-like dyes (eg, 712/20-nm filter)
  • Due to the excitation and emission characteristics of the acceptor dye, there may be moderate spillover into the Alexa Fluor™ 700 and PerCP-Cy5.5 detectors
  • However, the spillover can be corrected through compensation as with any other dye combination.