IDH1 (R132H) Recombinant Rabbit Monoclonal Antibody (RM390), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA544585-Each-of-1 | In Stock | ₹ 39,961.00 |
FEMA544585 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,961.00
GST (18%): ₹ 7,192.98
Total Price: ₹ 47,153.98
Antigen
IDH1 (R132H)
Classification
Recombinant Monoclonal
Concentration
100 μg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.
O75874
Gene Symbols
IDH1
Immunogen
A peptide corresponding to human (R132H mutant specific). The immunogen range is a synthetic peptide within amino acids 180-280 of human IDH1 with R132H mutant.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
RM390
Conjugate
Unconjugated
Gene
IDH1
Gene Alias
Cytosolic NADP-isocitrate dehydrogenase, epididymis luminal protein 216, epididymis secretory protein Li 26, HEL-216, HEL-S-26, IDCD, IDH, IDH1, IDH1-mutant, IDP, IDPC, isocitrate dehydrogenase (NADP(+)) 1, cytosolic, isocitrate dehydrogenase [NADP] cytoplasmic, isocitrate dehydrogenase 1 (NADP+), isocitrate dehydrogenase 1 (NADP+), soluble, NADP(+)-specific ICDH, NADP-dependent isocitrate dehydrogenase, cytosolic, NADP-dependent isocitrate dehydrogenase, peroxisomal, oxalosuccinate decarboxylase, PICD
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
3417
Content And Storage
-20°C
Isotype
IgG
Related Products
Description
- Isocitrate dehydrogenases such as IDH1 catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate
- These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+)
- Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic
- Each NADP(+)-dependent isozyme is a homodimer
- The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes
- It contains the PTS-1 peroxisomal targeting signal sequence
- The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid
- The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production
- This product is specific for IDH1 (mutant R132H).