JAK3 Recombinant Rabbit Monoclonal Antibody (1C7), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA549862-Each-of-1 | In Stock | ₹ 37,202.00 |
FEMA549862 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,202.00
GST (18%): ₹ 6,696.36
Total Price: ₹ 43,898.36
Antigen
JAK3
Classification
Recombinant Monoclonal
Concentration
1.5 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.
P52333
Gene Symbols
JAK3
Immunogen
A synthesized peptide derived from human JAK3
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Immunohistochemistry (Paraffin)
Clone
1C7
Conjugate
Unconjugated
Gene
JAK3
Gene Alias
Breast-JAK3, fae, JAK3, JAK-3, JAK3_HUMAN, JAK3B, JAKL, Janus kinase 3, Janus kinase 3 (a protein tyrosine kinase, leukocyte), Janus kinase 3 protein-tyrosine kinase, Janus kinase 3, protein-tyrosine kinase, L JAK, Leukocyte janus kinase, LJAK, L-JAK, RATJAK3, Tyrosine-protein kinase JAK3, wil
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3718
Content And Storage
-20°C or -80°C if preferred
Isotype
IgG
Related Products
Description
- Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family
- JAK3 is predominantly expressed in immune cells and transduces a signal in response to activation of interleukin receptors
- In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues
- The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus
- Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes
- JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier
- However, active JAK1 may be required for complex responses
- Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex.