FEMA550184
FPGS Recombinant Rabbit Monoclonal Antibody (30C11), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550184-Each-of-1 | In Stock | ₹ 37,202.00 |
FEMA550184 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,202.00
GST (18%): ₹ 6,696.36
Total Price: ₹ 43,898.36
Antigen
FPGS
Classification
Recombinant Monoclonal
Concentration
0.4 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.
Q05932
Gene Symbols
FPGS
Immunogen
A synthesized peptide derived from Human FPGS
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Flow Cytometry
Clone
30C11
Conjugate
Unconjugated
Gene
FPGS
Gene Alias
AA408187, folylpoly-gamma-glutamate synthetase, folylpolyglutamate synthase, folylpolyglutamate synthase, mitochondrial, folylpolyglutamyl synthetase, FPGS, Tetrahydrofolate synthase, tetrahydrofolylpolyglutamate synthase
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
2356
Content And Storage
-20°C or -80°C if preferred
Isotype
IgG
Related Products
Description
- Folylpoly-gamma-glutamate synthetase (FPGS) catalyzes the addition of several equivalents of glutamic acid to the gamma-carboxyl group in the side chain of folate cofactors and analogs
- Folylpoly-gamma-glutamate synthetase has three functions in folate homeostasis in mammals: polyglutamation prevents efflux of folate cofactors from the cell, it increases the binding of folate cofactors to some of the enzymes of folate interconversion and biosynthesis, and it appears to allow the accumulation of folates in the mitochondria that are required for glycine synthesis
- Folylpoly-gamma-glutamate synthetase is widely expressed in human tumors and is tightly linked either to proliferation or to a lack of differentiation
- The cytotoxicity of both thymidylate synthase and purine inhibitors requires continued inhibition of target for greater than one generation time, so that the integrative function of FPGS adds considerably to the efficiency of folate antimetabolites.