FEMA550294
Claudin 18 Monoclonal Antibody (2F8), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550294-Each-of-1 | In Stock | ₹ 32,307.00 |
FEMA550294 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 32,307.00
GST (18%): ₹ 5,815.26
Total Price: ₹ 38,122.26
Antigen
Claudin 18
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide
Gene Accession No.
P56856
Gene Symbols
Cldn18
Immunogen
Synthesized peptide derived from human Claudin 18
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Immunohistochemistry (Paraffin)
Clone
2F8
Conjugate
Unconjugated
Gene
Cldn18
Gene Alias
claudin 18, claudin 18-like, claudin-18, CLDN18, SFTA5, SFTPJ, surfactant associated 5, surfactant associated protein J, surfactant, pulmonary associated protein J, UNQ778/PRO1572
Host Species
Mouse
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
51208
Content And Storage
-20°C or -80°C if preferred
Isotype
IgG1 λ
Related Products
Description
- Claudin-18 is a tight junction protein expressed as lung-and stomach-specific isoforms which are generated by alternative splicing of the claudin-18 gene
- The lung-specific form is a downstream target gene regulated by the T/EBP/NKX2.1 transcription factor
- A splice variant lacking the C-terminal cytoplasmic domain also exists in mouse, but has not been confirmed in human
- Human claudin-18 demonstrates 88% amino acid sequence identity to the mouse protein
- Immunohistochemical studies have demonstrated complete membrane localization of claudin-18 in lung and stomach epithelial cells, while electron microscopy has shown that it is concentrated in the cell-cell borders of these cells
- These features suggest a potentially important role for claudin-18 in the structure and function of tight junctions in the lung and stomach
- Claudin-18 expression has also been reported in the inner ear.