Phospho-STAT3 (Tyr705) Recombinant Rabbit Monoclonal Antibody (HL1464), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550314-Each-of-1 | In Stock | ₹ 41,385.00 |
FEMA550314 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,385.00
GST (18%): ₹ 7,449.30
Total Price: ₹ 48,834.30
Antigen
Phospho-STAT3 (Tyr705)
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
P40763, P52631
Gene Symbols
STAT3
Immunogen
Carrier-protein conjugated synthetic peptide surrounding phospho Tyr705 of human STAT3. The exact sequence is proprietary.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Rat
Form
Liquid
Applications
Western Blot
Clone
HL1464
Conjugate
Unconjugated
Gene
STAT3
Gene Alias
1110034C02Rik, acute phase response factor, acute-phase response factor, ADMIO, ADMIO1, APRF, AW109958, DNA-binding protein APRF, FLJ20882, HIES, MGC16063, signal transducer and activator of transcription 3, signal transducer and activator of transcription 3 (acute-phase response factor), signal transducer, activator of transcription, acute-phase response factor, signal transduction and activation of transcription 3, STAT, STAT3, STAT-3, stat3 protein, STAT3b1, STAT3b2, transcription factor, Unknown (protein for MGC:128731), wu:fc15d02, wu:fl59g06, z-Stat3
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
25125, 6774
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Related Products
Description
- STAT3 belongs to the family of STAT (signal transducers and activators of transcription) proteins which are phosphorylated by receptor associated kinases, translocate to the nucleus, and act as transcription factors in response to cytokines and growth factors
- Coactivators such as CREB-binding protein are required for the transcriptional activation by STAT3
- STAT3 can also be activated by Interferon-alpha, Interferon-gamma, EGF, PDGF and IL6
- Phosphorylation on tyrosine 705 by JAK1 and JAK2 is essential for STAT3 dimer formation, nuclear translocation, and DNA binding activity
- In humans, the STAT3 gene is located on the q arm of chromosome 17
- STAT3 has been shown to be activated by IFN-alpha but not IFN-beta
- The transcription factors associated with STAT3 are c-Jun and cyclic AMP-responsive enhancer binding protein (CREB)
- STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis
- The small GTPase Rac1 has been shown to bind and regulate the activity of STAT3 while the PIAS3 protein is a specific inhibitor of STAT3
- Three alternatively spliced transcript variants encoding distinct isoforms of STAT3 have been described
- Deletion of the STAT3 gene in knock-out mice was lethal at the early embryonic stage.