FEMA550443
PKC gamma Recombinant Rabbit Monoclonal Antibody (HL2227), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550443-Each-of-1 | In Stock | ₹ 41,385.00 |
FEMA550443 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,385.00
GST (18%): ₹ 7,449.30
Total Price: ₹ 48,834.30
Antigen
PKC gamma
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
P05129, P63318, P63319
Gene Symbols
PRKCG
Immunogen
Recombinant fragmemt of human PKC gamma.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Clone
HL2227
Conjugate
Unconjugated
Gene
PRKCG
Gene Alias
PKC, Pkcc, PKCG, PKCgamma, PKC-gamma, PKCI, Prkc, Prkcc, PRKCG, protein kinase C gamma, protein kinase C gamma type, protein kinase C type I (gamma type), protein kinase C, gamma, RATPKCI, SCA14
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
18752, 24681, 5582
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Related Products
Description
- The PKC family of serine/threonine kinases, including PRKCG (PKC gamma), is activated intracellularly by signal transduction pathways
- In humans, at least 12 different PKC polypeptides have been identified
- These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity
- PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent
- Protein kinase C can be activated by calcium and second messenger diacylglycerol
- PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways
- PKC also serve as major receptors for phorbol esters, a class of tumor promoters
- Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells
- PKC gamma is one of the PKC family members
- This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons
- It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase
- Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development
- Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).