IL-1 beta Monoclonal Antibody (A7A10), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550586-Each-of-1 | In Stock | ₹ 41,741.00 |
FEMA550586 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,741.00
GST (18%): ₹ 7,513.38
Total Price: ₹ 49,254.38
Antigen
IL-1 beta
Classification
Monoclonal
Concentration
2 mg/mL
Formulation
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
P01584
Gene Symbols
IL1B
Immunogen
Recombinant protein within Human IL-1 beta aa 117-269/269.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Western Blot
Clone
A7A10
Conjugate
Unconjugated
Gene
IL1B
Gene Alias
catabolin, cytokine, Hematopoietin 1 (H1), IFN beta inducing factor, il 1b, IL 1β, IL-1, IL1 B, IL-1 beta, IL-1 precursor, IL1B, IL-1B, IL1B1, IL1beta, IL-1beta, IL1-BETA, IL1F2, IL1β, ILN, Interleukin, interleukin 1 beta, Interleukin 1 beta precursor, interleukin 1, beta, interleukin 1, beta 1, interleukin 1-beta, interleukin*1*beta, Interleukin1 beta, interleukin-1 beta, interleukin-1 beta precursor, interleukin-1 beta precursor (AA -113 to 153), interleukin-1 beta proprotein, interleukin-1b, interleukin-1beta, interleukin-beta, LAF, lymphocyte proliferation-potentiating factor, Osteoclast activating factor (OAF), preinterleukin 1 beta, Pro interleukin 1 beta, prointerleukin-1 beta, pro-interleukin-1-beta
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
3553
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG1
Related Products
Description
- Positive control: THP-1 treated with 80nM TPA overnight then treated with 100ng/mL LPS for 6 hours and 300ng/mL BFA for 3 hours whole cell lysate
- Predicted band size: 31 kDa Subcellular Location: Extracellular exosome, Secreted, Lysosome, Cytosol
- Product MA5-50586 was used in an Indirect ELISA
- Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells
- IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol
- Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals
- Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta
- IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism
- Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions
- IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha
- IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition
- IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury
- Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.