MLH1 Monoclonal Antibody (A9F7), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550627-Each-of-1 | In Stock | ₹ 41,741.00 |
FEMA550627 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,741.00
GST (18%): ₹ 7,513.38
Total Price: ₹ 49,254.38
Antigen
MLH1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
P40692, P97679, Q9JK91
Gene Symbols
Mlh1
Immunogen
Recombinant protein within human MLH1 aa 452-751/756.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
A9F7
Conjugate
Unconjugated
Gene
Mlh1
Gene Alias
1110035C23Rik, AI317206, AI325952, AI561766, COCA2, colon cancer, nonpolyposis type 2, DNA mismatch repair protein Mlh1, DNA mismatch repair protein Mlh1-like protein, FCC2, hMLH1, HNPCC, HNPCC2, I79_014127, MGC5172, mismatch repair protein 1, MLH1, MLH-1, mutL homolog 1, mutL homolog 1 (E. coli), mutL homolog 1, colon cancer, nonpolyposis type 2, mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli), mutL protein homolog 1
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
17350, 4292, 81685
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG2b
Related Products
Description
- Positive control: HeLa cell lysate, A549 cell lysate, HepG2 cell lysate, Jurkat cell lysate, NIH/3T3 cell lysate, F9 cell lysate, RAW264.7 cell lysate, C6 cell lysate, A431 cell lysate, Daudi cell lysate, K-562 cell lysate, HL-60 cell lysate, SW480 cell lysate, human colon carcinoma tissue, mouse colon tissue, rat small intestine tissue
- Predicted band size: 85 kDa Subcellular Location: Nucleus, Chromosome
- MLH1 is a DNA mismatch repair protein
- The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time
- An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI)
- These defects in DNA repair pathways have been related to human carcinogenesis
- The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC)
- MSHS2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process
- It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.