ErbB3 Recombinant Rabbit Monoclonal Antibody (R5), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550675-Each-of-1 | In Stock | ₹ 42,275.00 |
FEMA550675 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,275.00
GST (18%): ₹ 7,609.50
Total Price: ₹ 49,884.50
Antigen
ErbB3
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
P21860
Gene Symbols
ERBB3
Immunogen
Recombinant protein within Human HER3 aa 20-643/1342 (Extracellular)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
Flow Cytometry
Clone
R5
Conjugate
Unconjugated
Gene
ERBB3
Gene Alias
avian erythroblastosis oncogene B 3, avian erythroblastosis oncogene B 3 receptor, C76256, c-erbB3, c-erbB-3, C-errB-3, erb-b2 receptor tyrosine kinase 3, ERBB3, Erbb-3, Erbb3r, erbB3-S, glial growth factor receptor, HER3, human epidermal growth factor receptor 3, LCCS2, MDA BF 1, MDA-BF-1, MGC88033, nuc-ErbB3, p180 ErbB3, p180-ErbB3, p45 sErbB3, p45-sErbB3, p85 sErbB3, p85-sErbB3, proto-oncogene-like protein c-ErbB-3, receptor tyrosine kinase, receptor tyrosine-protein kinase erbB-3, receptor tyrosine-protein kinase erbB-3, LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3, tyrosine kinase-type cell surface receptor HER3, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
2065
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Related Products
Description
- Positive control: MCF-7, SK-Br-3
- Predicted band size: 148 kDa Subcellular Location: Cell membrane; Secreted
- ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family
- ErbB3 is over-expressed in a variety of tumors in the prostate, bladder, breast, stomach, pancreas, and colon
- Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents
- The ErbB3 gene is located on the long arm of human chromosome 12 (12q13) and is transcribed into a 6
- 2kb mRNA which is translated into a 160/180 kDa glycoprotein
- The ErbB3 gene encodes a transmembrane receptor tyrosine kinase due to alternative splicing and forms heterodimers with other EGF receptor family members that have kinase activity
- Heterodimerization leads to the activation of pathways that lead to cell proliferation or differentiation
- Alternate transcriptional splice variants encoding different isoforms of ErbB3 have been characterized
- One ErbB3 isoform lacks the intermembrane region, is secreted outside the cell, and acts to modulate the activity of the membrane-bound form
- Additional splice variants have also been reported, but they have not been thoroughly characterized.