CD21 Recombinant Rabbit Monoclonal Antibody (PD00-23), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550703-Each-of-1 | In Stock | ₹ 42,275.00 |
FEMA550703 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,275.00
GST (18%): ₹ 7,609.50
Total Price: ₹ 49,884.50
Antigen
CD21
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
P20023
Gene Symbols
CR2
Immunogen
Synthetic peptide within Human CD21 aa 1000 to the C-terminus.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed), Western Blot
Clone
PD00-23
Conjugate
Unconjugated
Gene
CR2
Gene Alias
C3b/C4b receptor, C3-binding protein, C3BR, C3DR, C4BR, CD21, CD35, CD35 antigen, cell surface receptor for C3d, complement C3b/C4b receptor 1 (Knops blood group), complement C3d receptor, Complement C3d receptor (C3DR), complement C3d receptor 2, complement component (3b/4b) receptor 1 (Knops blood group), complement component (3d/Epstein Barr virus) receptor 2, complement component 3b/4b receptor 1 (Knops blood group), complement component 3d receptor 2, complement component receptor 2, complement receptor 1 long isoform, complement receptor 2, complement receptor type 1, complement receptor type 1-like protein, complement receptor type 2, Complement Receptor type 2 (CR2), CR, CR1, Cr-1, CR1-L, Cr2, Cr-2, CVID7, EBV receptor, EBV-R, Epstein-Barr virus receptor, EVBR, expressed in B lymphocytes, KN, Knops blood group antigen, LOW QUALITY PROTEIN: complement receptor type 1, SLEB9
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
1380
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Related Products
Description
- Positive control: Raji cell lysates, human tonsil tissue, human spleen tissue, Raji, human prostate cancer
- Predicted band size: 113 kDa Subcellular Location: Cell membrane
- CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen
- CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens
- CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to follicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions
- A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands
- CD21 functions as receptor for C3d, C3dg and iC3b complement components, for EBV and for IFNalpha
- CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation
- Genetic variations in the CD21 gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9)
- Alternatively, spliced transcript variants encoding different isoforms of CD21 have been found.