GP6 Polyclonal Antibody, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEPA5145258-Each-of-1 | In Stock | ₹ 15,913.20 |
FEPA5145258 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 15,913.20
GST (18%): ₹ 2,864.376
Total Price: ₹ 18,777.576
Antigen
GP6
Classification
Polyclonal
Conjugate
Unconjugated
Gene
GP6
Gene Alias
9830166G18Rik, BDPLT11, Glycoprotein 5, glycoprotein 6, glycoprotein 6 (platelet), glycoprotein VI (platelet), glycoprotein VI platelet, Gm469, GP6, GPIV, GPVI, platelet collagen receptor, platelet glycoprotein VI
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
100517829, 51206
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
0.5 mg/mL
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Accession No.
Q9HCN6
Gene Symbols
GP6
Immunogen
Recombinant Human GP6 protein, Tyr86-Thr231 (Accession #Q9HCN6)
Quantity
20 μL
Primary or Secondary
Primary
Target Species
Human, Porcine
Form
Liquid
Related Products
Description
- Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets
- Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets
- Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels
- Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation
- In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss
- However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke.