GR11L100UG
MilliporeSigma™ anti-IGF-IR Clone: αIR3,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | GR11L100UG-Each-of-1 | In Stock | ₹ 59,102.23 |
GR11L100UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 59,102.23
GST (18%): ₹ 10,638.401
Total Price: ₹ 69,740.631
Antigen
IGF-IR
Classification
Monoclonal
Conjugate
Unconjugated
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Applications
Immunofluorescence, Immunoprecipitation
Clone
αIR3
Formulation
In 0.05M sodium phosphate buffer, 0.2% gelatin.
Immunogen
partially purified, human placenta IGF-I receptor
Regulatory Status
RUO
Test Specificity
Recognizes the ∽130kDa α and the ∽90kDa β subunits of IGF-I receptor.
Content And Storage
2°C to 8°C
Isotype
IgG1
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Description
- Specifically detects IGF-IR Clone: αIR3 in Human samples, and it is validated for Immunofluorescence, Immunoprecipitation The insulin-like growth factors (IGFs) or somatomedins are mitogenic peptides present in the plasma of human, rat, and other species
- Two distinct but chemically related IGFs have been purified from human plasma: IGF-I (Somatomedin C) and IGF-II
- They are single chain polypeptides with molecular weights of 7,640 and 7,471, respectively
- Types I and II IGF receptors differ in their structure and in their peptide binding specificity
- Type I IGF receptors are structurally homologous to insulin receptors and contain α-subunits (Mr=130,000) that bind peptide, and β-subunits (Mr=90,000), which have intrinsic tyrosine kinase activity
- The protein-tyrosine kinase activity of the insulin receptor and, presumably the IGF-I receptor, is required for insulin to stimulate all of its biological responses in cells
- Type II receptors are a single polypeptide (Mr=260,000), lack protein-tyrosine kinase activity, and have been shown to be identical to the mannose-6-phosphate receptor.