Alpha-Smooth Muscle Actin Monoclonal Antibody (1A4), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA106110-Each-of-1 | In Stock | ₹ 54,468.00 |
MA106110 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 54,468.00
GST (18%): ₹ 9,804.24
Total Price: ₹ 64,272.24
Antigen
Alpha-Smooth Muscle Actin
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
P08023, P62736, P62737, P62738
Gene Symbols
ACTA2, acta2.L
Immunogen
Peptide corresponding to residues E(1) E E D S T A L V C(10) of alpha-smooth muscle actin with an acetylated n-terminus coupled to KLH.
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Avian, Chicken, Goat, Human, Mouse, Non-human Primate, Ovine, Porcine, Rat, X. laevis
Product Type
Antibody
Isotype
IgG2a
Applications
Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunomicroscopy, Western Blot
Clone
1A4
Conjugate
Unconjugated
Gene
ACTA2
Gene Alias
0610041G09Rik; AAT6; ACT-4; acta2; acta2.L; acta2.S; actin; Actin Alpha 2 Smooth Muscle Aorta; actin alpha 2, smooth muscle; Actin Vascular Smooth Muscle; actin, alpha 2, smooth muscle, aorta; actin, alpha 2, smooth muscle, aorta L homeolog; actin, alpha 2, smooth muscle, aorta S homeolog; actin, alpha, vascular smooth muscle; actin, aortic smooth muscle; Actin, aortic smooth muscle, intermediate form; ACTSA; ACTVS; alpha actin 2; Alpha Cardiac Actin; alpha smooth muscle actin; alpha-actin; Alpha-actin-2; alpha-cardiac actin; alphaSMA; alpha-SM-actin; alpha-smooth muscle actin; Aortic Smooth Muscle; ASMA; a-sma; cell growth-inhibiting gene 46 protein; GIG46; Growth Inhibiting Gene 46; hypothetical protein LOC515610; LOW QUALITY PROTEIN: actin, aortic smooth muscle; mymy5; SM actin; sma; SMactin; sm-actin; SMalphaA; smooth muscle; smooth muscle alpha-actin; vascular smooth muscle alpha-actin; wu:fb63d03; XELAEV_18034370mg
Host Species
Mouse
Purification Method
purified
Regulatory Status
RUO
Gene ID (Entrez)
101121051, 102191486, 11475, 423787, 431847, 59, 733615, 81633
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- MA1-06110 detects a-smooth muscle actin (a-SM1) in human, rat, goat, porcine, non-human primate, quail, ovine, xenopus, monkey and chicken samples
- Since the epitope recognized by MA1-06110 is highly conserved, it can also cross-react with protochordates, lower craniates and mammals other than those specifically listed
- MA1-06110 has sucessfully been used in immunocytochemistry, immunomicroscopy, immunohistochemistry, and Western blotting procedures
- The MA1-06110 immunogen is a peptide corresponding to residues E(1) E E D S T A L V C(10) of alpha-smooth muscle actin with an acetylated n-terminus coupled to KLH
- MA1-06110 specifically recognizes the epitope Ac-EEED on alpha-smooth muscle actin
- Smooth Muscle Actin belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity
- Alpha, beta and gamma actin isoforms have been identified, with alpha actin being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility
- In particular, smooth muscle actin is an alpha actin that is found in skeletal muscle
- Actin exists as a ubiquitous protein involved with filament formation that make up large portions of the cytoskeleton
- Actin filaments interact with myosin to assist in muscle contraction as well as aiding in cell motility and cytokinesis
- Smooth muscle actin is found on smooth muscle vessel walls, gut wall, myometrium, myoepithelial cells in breast and salivary glands
- Defects in the smooth muscle actin gene cause aortic aneurysm familial thoracic type 6
- Actin isoforms differ slightly in their N-terminus and the sequences of each are perfectly conserved in higher vertebrates
- Alpha-smooth muscle actin is abundant in vascular and visceral smooth muscle cells
- In addition, it has also been shown that smooth muscle actin appear in stress fibers of fibroblastic cells during pathological situations involving contractile phenomena such as wound healing and fibrocontractive diseases
- Multiple alternatively spliced variants of smooth muscle actin have been identified.